Coordinates: Santa Sofia a Via Boccea is a church in Rome, Italy. It is dedicated to Holy Wisdom ("Sancta Sophia" in Latin), one of the seven gifts of the Holy Spirit. It served as the mother church of the Ukrainian Greek Catholic Church while St. George's Cathedral in Lviv was controlled by the Russian Orthodox Church.
The church is the national church for the Ukrainians in Rome, a meeting place and religious center for the community. The Divine Liturgy is celebrated according to the Byzantine-Ukrainian rite, whilst still in full communion with the Catholic Church.
The church was built in 1967-1968 on the orders of Cardinal Josyf Slipyj, the Major Archbishop of Lviv who had spent about 18 years in a Soviet gulag, and subsequently released but not allowed to return to Ukraine.
It is modeled after Kyiv's own Saint Sophia Cathedral. The relics of Pope Clement I (88-97) are kept in the church. Following the Byzantine rite, the church has an iconostasis, painted by Juvenalij Josyf Mokryckyj.
The first Cardinal-Priest of Santa Sofia was Myroslav Cardinal Lubachivsky. Lubomyr Cardinal Husar, MSU, Major Archbishop of Kyiv-Halych, held the titular church from his appointment as a cardinal on 21 February 2001 until his death in 2017.