Pazuzu is often depicted as a combination of diverse animal and human parts. He has the body of a man, the head of a lion or dog, talons of an eagle, two pairs of wings, a scorpion's tail and a serpentine penis. He has his right hand up and left hand down.
Pazuzu is the demon of the southwest wind known for bringing famine during dry seasons, and locusts during rainy seasons. Pazuzu was invoked in apotropaicamulets, which combat the powers of his rival, the malicious goddess Lamashtu, who was believed to cause harm to mother and child during childbirth. Although Pazuzu is, himself, considered to be an evil spirit, he drives and frightens away other evil spirits, therefore protecting humans against plagues and misfortunes.
Pazuzu is mentioned in the Simon Necronomicon, a publication of Avon Books that purports to document incantations to invoke "incredible things, beings, and monsters into visible form". He is described therein as "Lord of all fevers and plagues, grinning Dark Angel of the Four Wings, horned, with rotting genitalia", and as the "brother of HUMWAWA". The book claims that he is among the most fearsome of all entities, stating in part: "It is the able magician indeed who can remove PAZUZU once he has laid hold of a man, for PAZUZU lays hold unto death." Although the book makes the claim that Pazuzu (like all entities listed therein) was of Sumerian origin, critics John Wisdom Gonce III and Daniel Harms document the erroneous nature of such a claim, stating: "Likewise, the demon Pazuzu does not appear in myth until Assyria's rise in the first millennium B.C., long after Sumer's prime ... Thus the beings of the Simon Necronomicon bear little resemblance to either Sumerian myth or Lovecraftian fiction."
Pazuzu is the demon that allegedly haunts Adèle Blanc-Sec in Tardi's graphic novelThe Demon of the Eiffel Tower (Le Démon de la tour Eiffel, 1976). Pazuzu also appears in "Mummies on Parade" ("Momies en folie", 1978).
Pazuzu is featured in the 2014-15 NBC television series Constantine in a two-part episode "The Saint of Last Resorts". The protagonist, John Constantine, summons Pazuzu to combat Lamashtu, the primary antagonist of the first part, and later willingly allows Pazuzu to possess him to save himself from another powerful demon. However, Pazuzu has no wish to leave his new host, and emerges whenever Constantine is in danger, causing the deaths of at least eight dangerous gangbangers. Luckily, Constantine's ally Anne-Marie is able to exorcise Pazuzu by the end of the second part.
The podcast The Black Tapes, episode 108, explores a demon board called the "Zuzu" or Pazuzu board, designed to summon Pazuzu to the human world.
Pazuzu is Professor Farnsworth'sgargoyle in the tv show Futurama. He portrayed as dark red with dark purple wings, yellow eyes and light red horns. He escapes Professor Farnsworth and flies off to an unknown place. Professor Farnsworth goes after him but then forgets. When Professor Farnsworth is drowning in the Fountain of Aging, Pazuzu appears from under the Planet Express ship's starboard wing, diving into the fountain and saving Professor Farnsworth. He grants the Professor three wishes for putting him through college, one of which was to get him out of the Fountain of Aging in "Teenage Mutant Leela's Hurdles" and the second to get him out of prison in "The Beast with a Billion Backs", which he does. He currently lives in Paris.
In the 1992 SNES game Mystic Quest: Legend, Pazuzu appears as a boss character guarding the Crystal of Air. In this portrayal, he takes the form of a winged humanoid with a bird's head.