3D model (JSmol)
CompTox Dashboard (EPA)
|Appearance||dark red liquid|
|Main hazards||Toxic, dangerous for the environment|
|R-phrases (outdated)||R26 R27 R28 R33 R50 R53|
|S-phrases (outdated)||S13 S28 S36 S45 S60 S61|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
Merbromin (marketed as Mercurochrome, Merbromine, Mercurocol, Sodium mercurescein, Asceptichrome, Supercrome, Brocasept and Cinfacromin) is an organomercuric disodium salt compound used as a topical antiseptic for minor cuts and scrapes and as a biological dye. Readily available in most countries, it is no longer sold in Switzerland, Brazil, France, Iran, Germany, and the United States due to its mercury content.
Merbromin's best-known use is as a topical antiseptic to treat minor wounds, burns, and scratches. It is also used in the antisepsis of the umbilical cord and the antisepsis of wounds with inhibited scar formation, such as neuropathic ulcers and diabetic foot sores. When applied on a wound, it stains the skin a distinctive carmine red, which can persist up to two weeks through repeated washings. It is useful on infections of the finger or toe nails because of its permanence and lethality to bacteria.
Merbromin is also used as a biological dye to mark tissue margins and as a metal dye in industrial dye penetrant inspection to detect metal fractures.
Merbromin is synthesized by combining dibromofluorescein with mercuric acetate and sodium hydroxide or alternatively, through action of the mercuric acetate upon (or combining with) sodium dibromofluorescein. Because of its anionic character, it is chemically incompatible with acids (meaning that it can create dangerous exothermic or toxic gas reactions), the majority of alkaloid salts and most local anesthetics.
Merbromin is sold under the trade name Mercurochrome (where the suffix "- chrome" denotes "color"). The name is also commonly used for over-the-counter antiseptic solutions consisting of merbromin (typically at 2% concentration) dissolved in either ethyl alcohol (tincture) or water (aqueous).
Its antiseptic qualities were discovered in 1918 by Hugh H. Young, a physician at Johns Hopkins Hospital. The chemical soon became popular among parents and physicians for everyday antiseptic uses, including minor schoolyard injuries. Some people referred to it as "monkey blood," referring to its deep red color.
On 19 October 1998, citing potential for mercury poisoning, the Food and Drug Administration (FDA) reclassified merbromin from "generally recognized as safe" to "untested," effectively halting its distribution within the United States. Sales were subsequently halted in Brazil (2001), Germany (2003), and France (2006).[better source needed] It is readily available in most other countries.
Within the United States, products such as Humco Mercuroclear ("Aqueous solution of benzalkonium chloride and lidocaine hydrochloride") play on the brand recognition history of Mercurochrome but substitute other ingredients with similar properties. In Canada, Jean Coutu Group markets a chlorhexidine solution under the name Mercurochrome.
Se ha estudiado en 72 pacientes la eficacia de la merbromina comparativamente con la clorhexidina como antisépticos usados en la curación de múltiples afecciones en el pie diabético. Con el uso de merbromina se consigue disminuir apreciablemente el tiempo de cicatrización de las heridas, y se ha observado también una ausencia de complicaciones en los casos estudiados.