When the island was divided by the French and Spanish Empires in the 17th century, most Jews settled on the Spanish side which would later become the Dominican Republic. Eventually, Sephardim from other countries also arrived. In the 19th century Jews from Curaçao settled in Hispaniola, although they did not form a strong community. Most of them hid their Jewish identities or were unaffiliated with Jewish tradition by that time. Among their descendants were Dominican President Francisco Henríquez y Carvajal and his issue Pedro Henríquez Ureña, Max Henríquez Ureña, and Camila Henríquez Ureña.
The Dominican Republic was one of the very few countries willing to accept mass Jewish immigration during World War II. At the Évian Conference, it offered to accept up to 100,000 Jewish refugees. It is estimated that 5,000 visas were actually issued, and the vast majority of the recipients did not reach the country because of how hard it was to get out of occupied Europe. The DORSA (Dominican Republic Settlement Association) was formed with the assistance of the JDC, and helped settle Jews in Sosúa, on the northern coast. About 700 European Jews of Ashkenazi Jewish descent reached the settlement where each family received 33 hectares (82 acres) of land, 10 cows (plus 2 additional cows per child), a mule and a horse, and a US$10,000 loan (about 176,000 dollars at 2021 prices) at 1% interest. Other refugees settled in the capital, Santo Domingo. In 1943 the number of known Jews in the Dominican Republic peaked at 1000. Sosúa's Jewish community experienced a deep decline in the 1980s due to emigration during the touristic boom of Sosúa when most Jews sold their land to developers. The oldest Jewish grave is dated to 1826.
The Sephardic Jews that were exiled from Spain and the Mediterranean area in 1492 and 1497, coupled with other migrations dating from the 1700s and during World War II  contributed to Dominican ancestry. Some of the Sephardic Jews still presently reside in Sosúa while others are dispersed throughout the country. The number of known Jews (or those with genetic proof of Jewish ancestry and/or practiced Jewish customs/religion throughout generations) are close to 3,000; the exact number of Dominicans with Jewish lineages aren't known, however, because of intermarriage between the Jews and Dominicans over a period of more than five centuries.
The current population of known Jews in the Dominican Republic is close to 3,000, with the majority living in the capital, Santo Domingo, and others residing in Sosúa. Since Jews mixed with those already living in the Dominican Republic, the exact number of Dominicans with Jewish ancestry isn't known. In spite of the Jews intermarriage with the Dominican people already living there, some spouses have formalized their Judaism through conversions and participate in Jewish communal life while other Sephardic Jews converted to Catholicism, still maintaining their Sephardic culture. Some Dominican Jews have also made aliyah to Israel. There are three synagogues and one Sephardic Jewish Educational Center. One is the Centro Israelita de República Dominicana in Santo Domingo, another is a Chabad outreach center also in Santo Domingo, and another is in the country's first established community in Sosúa. Beth Midrash Eleazar , the Sephardic Educational Center, caters to those Jews who are descendants of the Sephardic Jews that migrated to Hispaniola in colonial times and later. In addition, they also provide kosher meat in the Beth Yoseph style, and supervise a small-scale kosher bakery. An "afterschool" at the Centro Israelita is active on a weekly basis and a chapter of the International Council of Jewish Women is also active. The Chabad outreach center  focuses on assisting the local Jewish population reconnect with their Jewish roots and (because Chabad is of the Chassidic Jewish tradition) it is a source for traditional Judaism in the Dominican Republic. In Sosua, there is a small Jewish Museum next to the synagogue. On the High Holidays, the Sosua community hires a cantor from abroad who comes to lead services.
A great deal of research on the subject of Dominican Jewry was done by Rabbi Henry Zvi Ucko who had been a writer and teacher in Germany until political conditions and growing anti-Semitism forced him to emigrate[when?]. His travels eventually took him to the Dominican Republic, where he organized a congregation in Santo Domingo (Ciudad Trujillo) and began researching the history of Jews in the country. His research covered much of the history of the Sephardic Jews there and documented the assimilation that the population went through (and was going through) during his time. Included in his research is correspondence with Haim Horacio López Penha, a Dominican Jewish writer, who encouraged Ucko to write a history of the Jews in the Dominican Republic. More recently, the publication of the book "Once Jews" has made easily available information on many early Jewish settlers in the Dominican Republic. Scholars such as the historian of the town of Baní, Manuel Valera, as well as Dr. Yehonatan Demota, continue the study of Dominican Sephardic and converso ancestry, and the question of the Dominican anusim.
Este apellido se origina en la península Ibérica, tanto en Portugal como en España, de familias judías sefardíes que marcharon posteriormente hacia el norte, llegando a Holanda, a raíz de la expulsión de judíos luego de la Reconquista. De allí parten hacia las colonias neerlandesas del Caribe, llegando a Curazao. En la República Dominicana, el tronco de esta familia fue Noel Henríquez Altías (n. 25 diciembre de 1813), natural de Curazao