Ferrante I Gonzaga (also Ferdinando I Gonzaga; 28 January 1507 - 15 November 1557) was an Italian condottiero, a member of the House of Gonzaga and the founder of the branch of the Gonzaga of Guastalla.
He was born in Mantua, the third son of Francesco II Gonzaga and Isabella d'Este. At the age of sixteen he was sent to the court of Spain as a page to the future emperor Charles V, to whom Ferrante remained faithful for his whole life. In 1527 he took part in the Sack of Rome and attended Charles' triumphant coronation at Bologna in 1530: at the death of Charles of Bourbon (1527) he was appointed commander-in-chief of the Imperial army in Italy. He became a Knight in the Order of the Golden Fleece in 1531.
He defended Naples from the assault of the French troops under Odet of Foix, Viscount of Lautrec, and obtained the surrender of the Republic of Florence. For this feat Pope Clement VII, a member of the Medici who had been ousted from that city, named him papal governor of Benevento. Again for Charles V, he fought against the Turks at Tunis in 1535 and Algiers in 1541 with a contingent of 3,000 cavalry. He served Charles as Viceroy of Sicily (1535-1546), and Forte Gonzaga was named in his honour. He accompanied the Emperor to Germany in 1543 and fought the resolute campaign that enforced the Treaty of Crépy. He then served as Governor of the Duchy of Milan (1546-1554), in which role he fought in the War of Parma.
In 1529 Ferrante married Isabella di Capua, who brought him the fiefdoms of Molfetta and Giovinazzo. In 1539 he bought the countship of Guastalla, on the left bank of the Po for 22,280 golden scudi from Countess Ludovica Torelli; it was in part a strategic purchase, for Guastalla lies near Ferrara, which Charles wished to take from the Este.
Ferrante's villa near Milan, La Gualtiera, is now known as La Simonetta. Ferrante rebuilt it in the 1550s, commissioning the services of the Tuscan architect Domenico Giuntallodi of Prato. Ferrante was a patron and protector of the sculptor and medallist Leone Leoni, who executed a bronze medal for him about 1555, with a reverse that depicts Hercules with upraised club besting the Nemean Lion and the legend TV NE CEDE MALIS, "You do not yield to evil", alluding to his acquittal after indictment for misappropriation of funds and corruption. His son Cesare commissioned from Leone a more public monument from Leone, a bronze Triumph of Ferrante Gonzaga over Envy, (1564), which stands in Piazza Roma, Guastalla. Like all the Gonzaga, Ferrante was a patron of tapestry-makers: a series Fructus Belli ("the Fruits of War") was woven for him, and a lighter series of Putti.
Ferrante was succeeded in Guastalla by his son Cesare.
Ferrante and Isabella had 11 children: