The Desaguadero River (Spanish: Río Desaguadero, Spanish pronunciation: ['ri.o ðesa?wa'ðe?o]) is a river in Argentina. Originating near the Tipas volcano in La Rioja at about 5,500 m (18,000 ft) elevation, the river is known in its upper reaches as the Bermejo or Vinchina. In its lower reaches it is also known as the Salado. It joins the Colorado River in La Pampa Province near Pichi Mahuida. The Desaguadero River has a total length of 1,498 km (931 mi) and its drainage basin is about 260,000 km2 (100,000 sq mi).
It is one of the major rivers that supplies the irrigated areas of Cuyo, and it flows in the eastern border of that region. Due to use of its waters for irrigation, the river is a small, shallow stream for most of the year despite its great length, and only occasionally does surface flow reach the Colorado.