Dandruff
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Dandruff

Dandruff
Other namesPityriasis capitis, pityriasis sicca[1]
Dandruff01.jpg
A microscopic image of human dandruff
SpecialtyDermatology
SymptomsItchy and flaking skin of the scalp[2][1]
Usual onsetPuberty[1]
CausesGenetic and environmental factors[1]
Diagnostic methodBased on symptoms[3]
Differential diagnosisPsoriasis, dermatitis, tinea capitis[2][1]
MedicationAntifungal cream (ketoconazole), salicylic acid[2][1]
Frequency~50% of adults[1]

Dandruff is a skin condition that mainly affects the scalp.[1] Symptoms include flaking and sometimes mild itchiness.[1][2] It can result in social or self-esteem problems.[4] A more severe form of the condition, which includes inflammation of the skin, is known as seborrhoeic dermatitis.[1]

The cause is unclear, but believed to involve a number of genetic and environmental factors;[1] the condition may worsen in the winter.[5] It is not due to poor hygiene,[6] and the underlying mechanism involves the excessive growth of skin cells.[5] Diagnosis is based on symptoms.[3]

There is no known cure for dandruff.[7] Antifungal cream, such as ketoconazole, or salicylic acid may be used to try to improve the condition.[1][2] Dandruff affects about half of adults, with males more often affected than females.[1] People in all areas of the world are affected.[1] Onset is usually at puberty and it becomes less common after the age of 50.[1]

Signs and symptoms

Severe dryness of scalp resulting in Dandruff.
Typical case of dandruff.

The signs and symptoms of dandruff are an itchy scalp and flakiness.[8] Red and greasy patches of skin and a tingly feeling on the skin are also symptoms.[9]

Causes

The cause is unclear but believed to involve a number of genetic and environmental factors.[10] The condition may worsen in the winter.[5] It is not due to poor hygiene.[6]

As the skin layers continually replace themselves, cells are pushed outward where they die and flake off. For most individuals, these flakes of skin are too small to be visible. However, certain conditions cause cell turnover to be unusually rapid, especially in the scalp. It is hypothesized that for people with dandruff, skin cells may mature and be shed in 2-7 days, as opposed to around a month in people without dandruff. The result is that dead skin cells are shed in large, oily clumps, which appear as white or grayish flakes on the scalp, skin and clothes.

According to one study, dandruff has been shown to be possibly the result of three factors:[11]

  1. Skin oil commonly referred to as sebum or sebaceous secretions[12]
  2. The metabolic by-products of skin micro-organisms (most specifically Malassezia yeasts)[13][14][15][16][17]
  3. Individual susceptibility and allergy sensitivity.

Microorganisms

Older literature cites the fungus Malassezia furfur (previously known as Pityrosporum ovale) as the cause of dandruff. While this species does occur naturally on the skin surface of people both with and without dandruff, in 2007 it was discovered that the responsible agent is a scalp specific fungus, Malassezia globosa,[18] that metabolizes triglycerides present in sebum by the expression of lipase, resulting in a lipid byproduct: oleic acid. During dandruff, the levels of Malassezia increase by 1.5 to 2 times its normal level.[5] Oleic acid penetrates the top layer of the epidermis, the stratum corneum, and evokes an inflammatory response in susceptible people which disturbs homeostasis and results in erratic cleavage of stratum corneum cells.[15]

Seborrhoeic dermatitis

In seborrhoeic dermatitis, redness and itching frequently occur around the folds of the nose and eyebrow areas, not just the scalp. Dry, thick, well-defined lesions consisting of large, silvery scales may be traced to the less common condition of scalp psoriasis. Inflammation can be characterized by redness, heat, pain or swelling, and can cause sensitivity.

Inflammation and extension of scaling outside the scalp exclude the diagnosis of dandruff from seborrhoeic dermatitis.[12] However, many reports suggest a clear link between the two clinical entities - the mildest form of the clinical presentation of seborrhoeic dermatitis as dandruff, where the inflammation is minimal and remain subclinical.[19][20]

Seasonal changes, stress, and immunosuppression seem to affect seborrheic dermatitis.[5]

Mechanism

Dandruff scale is a cluster of corneocytes, which have retained a large degree of cohesion with one another and detach as such from the surface of the stratum corneum. A corneocyte is a protein complex that is made of tiny threads of keratin in an organised matrix.[21] The size and abundance of scales are heterogeneous from one site to another and over time. Parakeratotic cells often make up part of dandruff. Their numbers are related to the severity of the clinical manifestations, which may also be influenced by seborrhea.[5]

Treatment

Ketoconazole (Nizoral) shampoo

Shampoos use a combination of special ingredients to control dandruff.[22]

Antifungals

Antifungal treatments including ketoconazole, zinc pyrithione and selenium disulfide have been found to be effective.[8] Ketoconazole appears to have a longer duration of effect.[8] Ketoconazole is a broad spectrum antimycotic agent that is active against Candida and M. furfur. Of all the antifungals of the imidazole class, ketoconazole has become the leading contender among treatment options because of its effectiveness in treating seborrheic dermatitis as well.[5]

Ciclopirox (topical route) may also be used as an anti-dandruff agent.[23][24][25] However it is mostly sold as cream and its main use is for treating athlete's foot, jock itch, and ringworm.[26]

Coal tar

Coal tar causes the skin to shed dead cells from the top layer and slows skin cell growth.[27]

Essential oils

Essential oils, such as tea tree oil (for composition, see ISO 4730:2017[28]), are found to be effective in the treatment of dandruff, but more research is required.[29][30][31]

Epidemiology

Dandruff affects around half of all adults.[8]

Etymology

According to the Oxford English Dictionary, the word dandruff is first attested in 1545, but is still of unknown etymology.[32]

References

  1. ^ a b c d e f g h i j k l m n o Tucker, D; Masood, S (January 2019). "Seborrheic Dermatitis". PMID 31869171. Cite journal requires |journal= (help)
  2. ^ a b c d e "Dandruff". nhs.uk. 18 October 2017. Retrieved 2020.
  3. ^ a b "Patient education: Seborrheic dermatitis (including dandruff and cradle cap) (Beyond the Basics)". www.uptodate.com. Retrieved 2020.
  4. ^ Grimalt, R. (December 2007). "A Practical Guide to Scalp Disorders". Journal of Investigative Dermatology Symposium Proceedings. 12 (2): 10-14. doi:10.1038/sj.jidsymp.5650048. PMID 18004290.
  5. ^ a b c d e f g Ranganathan, S; Mukhopadhyay, T (2010). "Dandruff: the most commercially exploited skin disease". Indian Journal of Dermatology. 55 (2): 130-4. doi:10.4103/0019-5154.62734. PMC 2887514. PMID 20606879.
  6. ^ a b "Dandruff: How to treat". American Academy of Dermatology. Archived from the original on 21 October 2017. Retrieved 2017.
  7. ^ Turkington, Carol; Dover, Jeffrey S. (2007). The Encyclopedia of Skin and Skin Disorders (Third ed.). Facts On File, Inc. p. 100. ISBN 978-0-8160-6403-8. Archived from the original on 19 May 2016.
  8. ^ a b c d Turner, GA; Hoptroff, M; Harding, CR (August 2012). "Stratum corneum dysfunction in dandruff". International Journal of Cosmetic Science. 34 (4): 298-306. doi:10.1111/j.1468-2494.2012.00723.x. PMC 3494381. PMID 22515370.
  9. ^ "What Is Dandruff? Learn All About Dandruff". Medical News Today. Archived from the original on 10 August 2015.
  10. ^ Borda, Luis J.; Wikramanayake, Tongyu C. (December 2015). "Seborrheic Dermatitis and Dandruff: A Comprehensive Review". Journal of Clinical and Investigative Dermatology. 3 (2). ISSN 2373-1044. PMC 4852869. PMID 27148560.
  11. ^ DeAngelis YM, Gemmer CM, Kaczvinsky JR, Kenneally DC, Schwartz JR, Dawson TL (2005). "Three etiologic facets of dandruff and seborrheic dermatitis: Malassezia fungi, sebaceous lipids, and individual sensitivity". J. Investig. Dermatol. Symp. Proc. 10 (3): 295-7. doi:10.1111/j.1087-0024.2005.10119.x. PMID 16382685.
  12. ^ a b Ro BI, Dawson TL (2005). "The role of sebaceous gland activity and scalp microfloral metabolism in the etiology of seborrheic dermatitis and dandruff". J. Investig. Dermatol. Symp. Proc. 10 (3): 194-7. doi:10.1111/j.1087-0024.2005.10104.x. PMID 16382662.
  13. ^ Ashbee HR, Evans EG (2002). "Immunology of Diseases Associated with Malassezia Species". Clin. Microbiol. Rev. 15 (1): 21-57. doi:10.1128/CMR.15.1.21-57.2002. PMC 118058. PMID 11781265.
  14. ^ Batra R, Boekhout T, Guého E, Cabañes FJ, Dawson TL, Gupta AK (2005). "Malassezia Baillon, emerging clinical yeasts". FEMS Yeast Res. 5 (12): 1101-13. doi:10.1016/j.femsyr.2005.05.006. PMID 16084129.
  15. ^ a b Dawson TL (2006). "Malassezia and seborrheic dermatitis: etiology and treatment". Journal of Cosmetic Science. 57 (2): 181-2. PMID 16758556.
  16. ^ Gemmer CM, DeAngelis YM, Theelen B, Boekhout T, Dawson Jr TL (2002). "Fast, Noninvasive Method for Molecular Detection and Differentiation of Malassezia Yeast Species on Human Skin and Application of the Method to Dandruff Microbiology". J. Clin. Microbiol. 40 (9): 3350-7. doi:10.1128/JCM.40.9.3350-3357.2002. PMC 130704. PMID 12202578.
  17. ^ Gupta AK, Batra R, Bluhm R, Boekhout T, Dawson TL (2004). "Skin diseases associated with Malassezia species". J. Am. Acad. Dermatol. 51 (5): 785-98. doi:10.1016/j.jaad.2003.12.034. PMID 15523360.
  18. ^ "Genetic code of dandruff cracked". BBC News. 6 November 2007. Archived from the original on 22 December 2008. Retrieved 2010.
  19. ^ Pierard-Franchimont C, Hermanns JF, Degreef H, Pierard GE (2006). "Revisiting dandruff". Int J Cosmet Sci. 28 (5): 311-318. doi:10.1111/j.1467-2494.2006.00326.x. PMID 18489295. S2CID 24519401.
  20. ^ Pierard-Franchimont C, Hermanns JF, Degreef H, Pierard GE. From axioms to new insights into dandruff. Dermatology 2000;200:93-8.
  21. ^ Brannon, Heather. "The Structure and Function of the Stratum Corneum". Dermatology.about.com. Archived from the original on 24 May 2015. Retrieved 2017.
  22. ^ "Best Dandruff Shampoo: What to Look for, 5 Products to Try". Healthline. 14 May 2020. Retrieved 2021.
  23. ^ Gupta, Aditya K.; Nicol, Karyn A. (January 2006). "Ciclopirox 1% shampoo for the treatment of seborrheic dermatitis". International Journal of Dermatology. 45 (1): 66-69. doi:10.1111/j.1365-4632.2004.02331.x. ISSN 0011-9059.
  24. ^ Gupta, A. K.; Bluhm, R. (June 2004). "Ciclopirox shampoo for treating seborrheic dermatitis". Skin Therapy Letter. 9 (6): 4-5. ISSN 1201-5989. PMID 15334279.
  25. ^ "Ciclopirox (Topical Route) Description and Brand Names - Mayo Clinic". www.mayoclinic.org. Retrieved 2021.
  26. ^ "Ciclopirox Topical: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD". www.webmd.com. Retrieved 2021.
  27. ^ GENERIC NAME(S): Coal TarFind Lowest Prices (16 August 2017). "Anti-Dandruff (coal tar)". WebMD. Archived from the original on 12 December 2010. Retrieved 2017.
  28. ^ 14:00-17:00. "ISO 4730:2017". ISO. Retrieved 2021.CS1 maint: numeric names: authors list (link)
  29. ^ Satchell, Andrew C.; Saurajen, Anne; Bell, Craig; Barnetson, Ross StC. (December 2002). "Treatment of dandruff with 5% tea tree oil shampoo". Journal of the American Academy of Dermatology. 47 (6): 852-855. doi:10.1067/mjd.2002.122734.
  30. ^ Pazyar, Nader; Yaghoobi, Reza; Bagherani, Nooshin; Kazerouni, Afshin (July 2013). "A review of applications of tea tree oil in dermatology". International Journal of Dermatology. 52 (7): 784-790. doi:10.1111/j.1365-4632.2012.05654.x.
  31. ^ "Tea tree oil". Mayo Clinic. Retrieved 2021.
  32. ^ "dandruff | dandriff, n." OED Online. Oxford University Press, March 2015. Web. Retrieved 27 April 2015.

External links


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Dandruff
 



 



 
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