Vesicular Glutamate Transporter 3
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Vesicular Glutamate Transporter 3
AliasesSLC17A8, DFNA25, VGLUT3, solute carrier family 17 member 8
External IDsOMIM: 607557 MGI: 3039629 HomoloGene: 13584 GeneCards: SLC17A8
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for SLC17A8
Genomic location for SLC17A8
Band12q23.1Start100,357,074 bp[1]
End100,422,055 bp[1]
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 12: 100.36 - 100.42 MbChr 10: 89.57 - 89.62 Mb
PubMed search[3][4]

Vesicular glutamate transporter 3 (VGLUT3) is a protein that in humans is encoded by the SLC17A8 gene.[5]


This gene encodes a vesicular glutamate transporter. The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft.[5]

Clinical significance

Mutations in this gene are the cause of autosomal-dominant nonsyndromic deafness type 25 (DFNA25).[6][7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000179520 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019935 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter)".
  6. ^ Online Mendelian Inheritance in Man (OMIM) 605583
  7. ^ Ruel J, Emery S, Nouvian R, et al. (August 2008). "Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null mice". Am. J. Hum. Genet. 83 (2): 278-92. doi:10.1016/j.ajhg.2008.07.008. PMC 2495073. PMID 18674745.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  This article uses material from the Wikipedia page available here. It is released under the Creative Commons Attribution-Share-Alike License 3.0.



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