She has released one album on Lyric Street Records, and has charted five singles on the Billboard Hot Country Songs charts. Three were included on her self-titled debut album, released in 2000. A fourth was a Christmas single included on the label's multi-artist collection No Wrapping Required: A Christmas Album. Her highest-charting single, "No Regrets Yet", peaked at number 36 on the country charts but did not appear on an album.
She parted ways with Lyric Street in 2004. Isaacs, along with several of her family members, also comprise a gospel music band called The Isaacs. Sonya recorded the song "The Battlefield" for the soundtrack to the 2006 film Broken Bridges. She and Vince Gill contributed guest vocals to a cover of "Misty" on Cledus T. Judd's 2007 tribute album Boogity, Boogity -- A Tribute to the Comedic Genius of Ray Stevens.
She also sang a duet with Dolly Parton to "The Angels Rejoiced".
Sonya and Jimmy welcomed baby boy Ayden James Yeary on July 26, 2011. In 2014, Sonya carried a baby girl for nearly six months before doctors told her there was no heartbeat. Ayva Devorah Yeary was stillborn on October 13, 2014. Gatlyn Solomon Yeary was born on December 8, 2015, and the couple welcomed a daughter, Evya Marcella Yeary, on March 31, 2017.
|1999||"On My Way to You"||54||Sonya Isaacs|
|2000||"I've Forgotten How You Feel"[A]||46|
|"Since I Gave My Heart Away"||--||Gepetto (soundtrack)|
|"Barefoot in the Grass"||64||Sonya Isaacs|
|"How Can I Forget"||--|
|2002||"Baby Don't You Let Go"||--||Pictures of Me (unreleased)|
|2003||"No Regrets Yet"||36|
|"--" denotes releases that did not chart|
|2002||"What Do You See"||59||No Wrapping Required: A Christmas Album|