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Solanum americanum is one of the most widespread and morphologically variable species belonging to the section Solanum. It can be confused with other black nightshade species in the Solanum nigrum complex.
Solanum americanum grows up to 1-1.5 metres (39-59 in) tall and is an annual or short-lived perennial. The leaves are alternate on the branch, and vary greatly in size, up to 10 centimetres (3.9 in) long and 7 centimetres (2.8 in) broad, with a 4-centimetre (1.6 in) petiole and a coarsely wavy or toothed margin. The flowers are about 1 cm diameter, white or occasionally light purple, with yellow stamens. The fruit is a shiny black berry 5-10 millimetres (0.20-0.39 in) diameter, containing numerous small seeds.
Solanum americanum is a variable taxon. It is considered by some botanists to be more than one species, and others recognise subspecies. Some botanists have suggested that Solanum americanum may be conspecific with the European nightshade, S. nigrum.
Significant amounts of solasodine (0.65%) have been found in the green berries. The ripe fruit also contains 0.3-0.45% solasonine, and acetylcholine, and has a cholinesterase-inhibiting effect on human plasma. In Transkei, rural people have a high incidence of esophageal cancer thought to be a result of using S.americanum as a food. Livestock can also be poisoned by high nitrate levels in the leaves.
Toxicity varies widely depending on the genetic strain and the location conditions, like soil and rainfall. Poisonous plant experts advise: "...unless you are certain that the berries are from an edible strain, leave them alone." 
Medina, Freddy R.; Ritchie, Lawrence S. (October-December 1980). "Molluscicidal Activity of the Puerto Rican Weed, Solanum nodiflorum, against Snail Hosts of Fasciola hepatica". Economic Botany. 34 (4): 368-375. doi:10.1007/bf02858313. JSTOR4254217.