The area around Seki-juku was always a major intersection for travel. During the time of the Jinshin War, it was known as one of the Three Ancient Seki, being called the Ise Suzuka Seki (, Ise Suzuka Barrier), and was an administrative checkpoint on the highway to the eastern provinces.
During the Edo period, the area flourished as a lively post town, because both the Isebetsu Kaid? (), a highway for pilgrims to the Ise Grand Shrines and the Yamato Kaid? (?), a highway for travelers to Yamato Province, intersected here with the T?kaid? highway. Following the Meiji Restoration, Seki-juku became the nucleus for the modern town of Seki, which became part of the city of Kameyama in 2005.
The classic ukiyo-e print by And? Hiroshige (H?eido edition) from 1831-1834 depicts the retinue of a daimy? on sankin-k?tai preparing to leave an upper-class inn during the early hours of the morning.
Many of the historical buildings have been preserved and the area has been designated as Important Preservation District for Groups of Traditional Buildings.