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People of the surname Saussure or de Saussure include
- Horace-Bénédict de Saussure (1740-1799), Genevan physicist and Alpine traveller
- Henri Louis Frédéric de Saussure (1829-1905), Swiss mineralogist and entomologist (taxonomist), and father of Ferdinand, Léopold and René.
- Ferdinand de Saussure (1857-1913), Swiss linguist, brother of Léopold and René
- Léopold de Saussure (1866-1925), sinologist, astronomer, French Naval Officer, brother of Ferdinand and René
- René de Saussure (1868-1943), Swiss Esperantist and scientist, brother of Ferdinand and Léopold
- Éric de Saussure (1925-2007), Swiss artist and member of the Taizé Community
- Henry William de Saussure (1763-1839) American lawyer, State legislator from South Carolina, President of the U.S. Mint