Excitatory amino acid transporter 3 is a member of the high-affinity glutamate transporters which plays an essential role in transporting glutamate across plasma membranes in neurons. In the brain, excitatory amino acid transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. EAAT3 also transports aspartate, and mutations in this gene are thought to cause dicarboxylic aminoaciduria, also known as glutamate-aspartate transport defect. EAAT3 is also the major route of neuronal cysteine uptake. Cysteine is a component of the major antioxidant glutathione, and mice lacking EAAT3 exhibit reduced levels of glutathione in neurons, increased oxidative stress, and age-dependent loss of neurons, especially neurons of the substantia nigra. A meta-analysis identified a small but significant association between a polymorphism of the gene SLC1A1 and Obsessive-Compulsive Disorder.
^Smith CP, Weremowicz S, Kanai Y, Stelzner M, Morton CC, Hediger MA (March 1994). "Assignment of the gene coding for the human high-affinity glutamate transporter EAAC1 to 9p24: potential role in dicarboxylic aminoaciduria and neurodegenerative disorders". Genomics. 20 (2): 335-6. doi:10.1006/geno.1994.1183. PMID8020993.
Nieoullon A, Canolle B, Masmejean F, Guillet B, Pisano P, Lortet S (August 2006). "The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse?". Journal of Neurochemistry. 98 (4): 1007-18. doi:10.1111/j.1471-4159.2006.03978.x. PMID16800850.
Shashidharan P, Huntley GW, Meyer T, Morrison JH, Plaitakis A (October 1994). "Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain". Brain Research. 662 (1-2): 245-50. doi:10.1016/0006-8993(94)90819-2. PMID7859077.
Kanai Y, Stelzner M, Nussberger S, Khawaja S, Hebert SC, Smith CP, Hediger MA (August 1994). "The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport". The Journal of Biological Chemistry. 269 (32): 20599-606. PMID7914198.
Bar-Peled O, Ben-Hur H, Biegon A, Groner Y, Dewhurst S, Furuta A, Rothstein JD (December 1997). "Distribution of glutamate transporter subtypes during human brain development". Journal of Neurochemistry. 69 (6): 2571-80. doi:10.1046/j.1471-4159.1997.69062571.x. PMID9375691.
Veenstra-VanderWeele J, Kim SJ, Gonen D, Hanna GL, Leventhal BL, Cook EH (March 2001). "Genomic organization of the SLC1A1/EAAC1 gene and mutation screening in early-onset obsessive-compulsive disorder". Molecular Psychiatry. 6 (2): 160-7. doi:10.1038/sj.mp.4000806. PMID11317217.
Borre L, Kavanaugh MP, Kanner BI (April 2002). "Dynamic equilibrium between coupled and uncoupled modes of a neuronal glutamate transporter". The Journal of Biological Chemistry. 277 (16): 13501-7. doi:10.1074/jbc.M110861200. PMID11823462.
Vallejo-Illarramendi A, Domercq M, Pérez-Cerdá F, Ravid R, Matute C (January 2006). "Increased expression and function of glutamate transporters in multiple sclerosis". Neurobiology of Disease. 21 (1): 154-64. doi:10.1016/j.nbd.2005.06.017. PMID16061389.