Psychedelic Microdosing
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Psychedelic Microdosing

Psychedelic microdosing is a practice to use sub-threshold doses of psychedelic drugs in an attempt to improve creativity, boost physical energy level, emotional balance, increase performance on problems-solving tasks and to treat anxiety, depression and addiction. [1][2]

A microdose is usually a tenth of an active dose of psychedelic drugs. This practice has become more widespread in the 21st century.[3]

In 2018, a group of scientists at Imperial College London announced a self-blinding study recruiting volunteers across the globe via Internet, using questionnaires and games to evaluate psychological well-being and cognitive function effects of psychedelic microdosing.[4]

A study published in 2019 tested the microdosing hypothesis by subjecting male and female Sprague Dawley rats to behavioral testing following the chronic, intermittent administration of low doses of the psychedelic N,N-dimethyltryptamine (DMT). The behavioral and cellular effects of this dosing regimen were distinct from those induced following a single high dose of the drug. The study found that chronic, intermittent, low doses of DMT produced an antidepressant-like phenotype and enhanced fear extinction learning without impacting working memory or social interaction. Additionally, male rats treated with DMT on this schedule gained a significant amount of body weight during the course of the study. Taken together, results suggest that psychedelic microdosing may alleviate symptoms of mood and anxiety disorders, though the potential hazards of this practice warrant further investigation.[5]

See also


  1. ^ Fadiman, James (2016-01-01). "Microdose research: without approvals, control groups, double blinds, staff or funding". Psychedelic Press. XV.
  2. ^ "The truth about 'microdosing,' which involves taking tiny amounts of psychedelics like LSD". Business Insider. Retrieved: 2017-04-19.
  3. ^ "A Brief History of LSD in the Twenty-First Century". Psychedelic Press UK. Retrieved: 2017-04-19.
  4. ^ "Self-blinding microdosing study".
  5. ^ Cameron LP, Benson CJ, DeFelice BC, Fiehn O, Olson DE (July 2019). "N-Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents". ACS Chemical Neuroscience. 10 (7): 3261-3270. doi:10.1021/acschemneuro.8b00692. PMC 6639775. PMID 30829033.

  This article uses material from the Wikipedia page available here. It is released under the Creative Commons Attribution-Share-Alike License 3.0.



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