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Paropamisadae or Parapamisadae (Greek) was a satrapy of the Alexandrian Empire in modern Afghanistan and Pakistan, which largely coincided with the Achaemenid province of Parupraesanna. It consisted of the districts of Sattagydia, Gandhara, Buner and Udyana. Paruparaesanna is mentioned in the Akkadian language and Elamite language versions of the Behistun Inscription of Darius the Great, whereas in the Old Persian version it is called Gand?ra. The entire satrapy was subsequently ceded by Seleucus I Nicator to Chandragupta Maurya following a treaty.
Paropamisadae is the Latinized form of the Greek name Paropamisádai (?), which is in turn derived from Old Persian Parupraesanna. The latter means "Beyond the Hindu Kush", where the Hindu Kush is referred to as Uparaesanna ("higher than the eagle").
In the Greek language and Latin, "Paropamisus" (, Paropamisós) came to mean the Hindu Kush.[a] In many Greek and Latin sources, particularly editions of Ptolemy's Geography where their realm is included on the 9th Map of Asia, the names of the people and region are given as Paropanisadae and Paropanisus. They also appeared less frequently as Parapamisadae and Parapam?sus (, Parapámisos),Paropam?sii, etc.
The name was also applied to a nearby river, probably the Obi river.
Strabo describes the region as follows:
The geographical position of the tribes is as follows: along the Indus are the Paropamisadae, above whom lies the Paropamisus mountain; then, towards the south, the Arachoti; then next, towards the south, the Gedroseni, with the other tribes that occupy the seabord; and the Indus lies, latitudinally, alongside these places; and of these places, in part, some that lie along the Indus are held by Indians, although they formerly belonged to the Persians. Alexander took these away from the Arians and established settlements of his own, but Seleucus I Nicator gave them to Sandrocottus, upon terms of intermarriage and of receiving in exchange 500 elephants.
Alongside the Paropamisadae, on the west, are situated the Arii, and alongside the Arachoti and Gedrosii the Drangae; but the Arii are situated alongside the Drangae on the north as well as on the west, almost surrounding a small part of their country.
Thus the region was north of Arachosia, stretching up to the Hindu Kush and Pamir mountains, and bounded in the east by the Indus river. It mainly included the Kabul region, Gandhara and the northern regions such as Swat and Chitral.
The nations who composed the Paropamisadae are recorded as the Cabolitae () in the north near modern Kabul; the Parsii (?) in the northwest, the Ambautae () in the east and the Par(g)yetae ((?)) in the south, who were also found in Arachosia. The major cities of the land were the city of Ortospana () or Carura (?), probably identifiable with Kabul, Gauzaca (?), probably modern Ghazni, Capissa (?), modern-day Kapisa, and Parsia (), the capital of the Parsii.
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In the ancient Buddhist texts, the Mahajanapada kingdom of Kamboja compassed the territories of Paropamisus and extended to the southwest of Kashmir as far as Rajauri. The region came under Achaemenid Persian control in the late 6th century BC, either during the reign of Cyrus the Great or Darius I.
In the 320s BC, Alexander the Great conquered the entire Achaemenid Empire, beginning the Hellenistic period. The Greek name ? or was used extensively in Greek literature to describe the conquests of Alexander and those of the kings of the Greco-Bactrian Kingdom and the Indo-Greek Kingdom, from the 3rd to the 1st centuries BC. (The name possibly comes from an Avestan expression for "higher than an eagle can fly").
After Alexander's death in 323 BC, the area came under control of the Seleucid Empire, which gave the region to the Mauryan Dynasty of India in 305 BC. After the fall of the Mauryans in 185 BC, the Greco-Bactrians under King Demetrius I annexed the northwestern regions of the former Mauryan Empire, including Paropamisus, and it became part of his Euthydemid Indo-Greek Kingdom. The Eucratidians seized the area soon after the death of Menander I, but lost it to the Yuezhi around 125 BC.