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Clinical data
SynonymsHerchst 10495, NIH-7557
ATC code
  • None
Legal status
Legal status
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.008.383 Edit this at Wikidata
Chemical and physical data
Molar mass335.483 g/mol g·mol-1
3D model (JSmol)

Norpipanone (INN, BAN; Hexalgon) is an opioid analgesic related to methadone which was developed in Germany and distributed in Hungary, Argentina, and other countries.[1][2] It had originally not been under international control but upon observation of case reports of addiction it was reviewed and shortly thereafter became a controlled substance.[1][2] In the United States, it is a Schedule I controlled substance (ACSCN 9636, zero annual manufacturing quota as of 2014). The salts in use are the hydrobromide (free base conversion ratio 0.806) and hydrochloride (0.902).


Norpipanone synthesis:[3][4]

See also


  1. ^ a b John B Buckingham (December 1995). Dictionary of Organic Compounds. CRC Press. p. 2883. ISBN 978-0-412-54090-5. Retrieved 2012.
  2. ^ a b David S. Patterson (12 March 2002). Foreign Relations of the United States, 1961-1963, Volume XXV: Organization of Foreign Policy; Information Policy; United Nations; Scientific Matters. Government Printing Office. pp. 766-767. ISBN 978-0-16-050885-1. Retrieved 2012.
  3. ^ Duprè, D. J.; Elks, J.; Hems, B. A.; Speyer, K. N.; Evans, R. M. (1949). "113. Analgesics. Part I. Esters and ketones derived from ?-amino-?-cyano-diarylalkanes". Journal of the Chemical Society (Resumed). Chemical Society: 500. doi:10.1039/JR9490000500.
  4. ^ Bockmühl, M.; Ehrhart, G. (1949). "Über eine neue Klasse von spasmolytisch und analgetisch wirkenden Verbindungen, I". Justus Liebigs Annalen der Chemie. 561: 52. doi:10.1002/jlac.19495610107.

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