Archaeologists have proposed that Kfar Kama was the village Helenoupolis that Constantine established in honor of his mother Helen.Excavations carried out in 1961 and 1963 revealed 4th century tombs. Two churches dated to the early 6th century, one dedicated to Saint Thecla, were uncovered, with multicolored mosaics of floral, animal and geometric patterns.
In the Crusader period it was known as Kapharchemme or Capharkeme.
Ruins and parts of five limestone columns were found in addition to a circular basalt olive-press and cisterns.
Circassians in traditional garb, Kfar Kama
In 1596, Kfar Kama appeared in Ottomantax registers as a village in the Nahiya of Tiberias in the Liwa of Safad. It had a population of 34 Muslim households and paid a fixed tax rate of 25% on agricultural products, which included wheat, barley, summer crops, cotton, and goats or beehives; a total of 5,450 akçe.
A population survey in 1887 found 1,150 inhabitants, all Circassian Muslims. 
British Mandate era
Mosque next to Circassian Heritage Center in Kfar Kama
At the time of the 1922 census of Palestine, Kfar Kama had a population of 670 Muslims and 7 Christians, decreasing slightly in the 1931 census to 644, one Christian and the rest Muslims, in a total of 169 houses.
Kfar Kama is one of two Circassian villages in Israel. The other one is Rehaniya. The Circassians are Muslims, who unlike the main Israeli Arab Muslim minority, perform military service in the IDF.The village school teaches in Circassian, Hebrew, Arabic and English.
A Center for Circassian Heritage is situated in the village.
^ abcNirit Reichel (2010). "The role of the educational system in retaining Circassian identity during the transition from Ottoman control to life as Israeli citizens (1878-2000)". Israel Affairs. 16: 251-267. doi:10.1080/13537121003643896.