Manasse studied clarinet at the Juilliard School under David Weber. He won a prize in the International Competition for Clarinet in Munich and was the youngest winner of the International Clarinet Society Competition.
Manasse has performed at the Lincoln Center in New York, Columbia University, and Rockefeller University. He has toured in Japan and Southeast Asia with the New York Symphonic Ensemble, and played in Jerusalem, Tel Aviv and Osaka. He has been a guest soloist with the National Philharmonic, Symphony Nova Scotia, National Chamber Orchestra, New York Philharmonic, and the orchestras of Alabama, Annapolis, Bozeman, Dubuque, Evansville, Florida West Coast, Green Bay, Indianapolis, Jackson, Oakland East Bay, Pensacola, Princeton, and Richmond. He has also been the guest principal clarinetist of the New York Pops Orchestra, Orpheus Chamber Orchestra, New Jersey Symphony Orchestra, St. Louis Symphony Orchestra, and Seattle Symphony Orchestra. He was also a member of the New York Chamber Symphony and the Metropolitan Opera Orchestra.
Manasse plays with the Stamford Symphony Orchestra, and is the principal clarinetist of the American Ballet Theater Orchestra and the Mostly Mozart Festival Orchestra. He became the principal clarinetist of the Orchestra of St. Luke's in 2008. Jon Manasse and his duo-partner, pianist Jon Nakamatsu, serve as Artistic Directors of the Cape Cod Chamber Music Festival. Manasse is a Buffet Crampon and Vandoren Performing Artist. He has been Associate Professor of Clarinet at the Eastman School of Music since 1995, faculty member of Juilliard in 2007, and distinguished artist in residence at Lynn University's Conservatory of Music since 2008 in Boca Raton, Florida.
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