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JWH-307 is an analgesic drug used in scientific research, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It is somewhat selective for the CB2 subtype, with a Ki of 7.7 nM at CB1 vs 3.3 nM at CB2.[1] It was discovered by, and named after, John W. Huffman. JWH-307 was detected as an ingredient in synthetic cannabis smoking blends in 2012, initially in Germany.[2][3]

In the United States, CB1 receptor agonists of the 3-(1-naphthoyl)pyrrole class such as JWH-307 are Schedule I Controlled Substances.[4]

See also


  1. ^ Huffman JW, Padgett LW, Isherwood ML, Wiley JL, Martin BR. 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: New high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorganic & Medicinal Chemistry Letters 2006; 16:5432-5435.
  2. ^ Ernst, L.; Krüger, K.; Lindigkeit, R.; Schiebel, H. M.; Beuerle, T. (2012). "Synthetic cannabinoids in "spice-like" herbal blends: First appearance of JWH-307 and recurrence of JWH-018 on the German market". Forensic Science International. 222 (1-3): 216-22. doi:10.1016/j.forsciint.2012.05.027. PMID 22748479.
  3. ^ Kneisel, S.; Auwärter, V. (2012). "Analysis of 30 synthetic cannabinoids in serum by liquid chromatography-electrospray ionization tandem mass spectrometry after liquid-liquid extraction". Journal of Mass Spectrometry. 47 (7): 825-835. doi:10.1002/jms.3020. PMID 22791249.
  4. ^ 21 U.S.C. § 812: Schedules of controlled substances

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