Get JWH-203 essential facts below. View Videos or join the JWH-203 discussion. Add JWH-203 to your PopFlock.com topic list for future reference or share this resource on social media.
Legal status
Legal status
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.233.381 Edit this at Wikidata
Chemical and physical data
Molar mass g·mol-1
3D model (JSmol)

JWH-203 (1-pentyl-3-(2-chlorophenylacetyl)indole) is an analgesic chemical from the phenylacetylindole family that acts as a cannabinoid agonist with approximately equal affinity at both the CB1 and CB2 receptors, having a Ki of 8.0 nM at CB1 and 7.0 nM at CB2. It was originally discovered by, and named after, Dr. John W. Huffman, but has subsequently been sold without his permission as an ingredient of synthetic cannabis smoking blends.[2] Similar to the related 2'-methoxy compound JWH-250, the 2'-bromo compound JWH-249, and the 2'-methyl compound JWH-251, JWH-203 has a phenylacetyl group in place of the naphthoyl ring used in most aminoalkylindole cannabinoid compounds, and has the strongest in vitro binding affinity for the cannabinoid receptors of any compound in the phenylacetyl group.[3][4][5]

Unexpectedly despite its weaker CB1 Kiin vitro, the 2-methylindole derivative JWH-204 is actually more potent than JWH-203 in animal tests for cannabinoid activity, though it is still weaker than JWH-249.[6]


Legal status

In the United States, JWH-203 is a Schedule I Controlled Substance.[7]

As of October 2015, JWH-203 is a controlled substance in China.[8]

See also


  1. ^ = WDU20111050614 "Ustawa z dnia 15 kwietnia 2011 r. o zmianie ustawy o przeciwdzia?aniu narkomanii ( Dz.U. 2011 nr 105 poz. 614 )" Check |url= value (help). Internetowy System Aktów Prawnych. Retrieved 2011.
  2. ^ Bononi, Monica; Belgi, Paolo; Tateo, Fernando (July 2011). "Analytical data for identification of the Cannabimimetic Phenylacetylindole JWH-203" (PDF). J Anal Toxicol. 35 (6): 360-3. doi:10.1093/anatox/35.6.360. PMID 21740693.
  3. ^ Huffman, JW; et al. (2005). "1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles". Bioorganic & Medicinal Chemistry Letters. 15 (18): 4110-3. doi:10.1016/j.bmcl.2005.06.008. PMID 16005223.
  4. ^ Manera, C; Tuccinardi, T; Martinelli, A (2008). "Indoles and related compounds as cannabinoid ligands". Mini Reviews in Medicinal Chemistry. 8 (4): 370-87. doi:10.2174/138955708783955935. PMID 18473928.
  5. ^ Bononi M, Belgi P, Tateo F (2011). "Analytical data for identification of the Cannabimimetic Phenylacetylindole JWH-203" (PDF). Journal of Analytical Toxicology. 35 (6): 360-3. doi:10.1093/anatox/35.6.360. PMID 21740693.
  6. ^ Wiley, Jenny L.; Marusich, Julie A.; Martin, Billy R.; Huffman, John W. (November 2011). "1-Pentyl-3-phenylacetylindoles and JWH-018 share in vivo cannabinoid profiles in mice". Drug Alcohol Depend. 123 (1-3): 148-153. doi:10.1016/j.drugalcdep.2011.11.001. PMC 3294131. PMID 22127210.
  7. ^ "Controlled Substances" (PDF). Drug Enforcement Agency.
  8. ^ "" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 2015.

  This article uses material from the Wikipedia page available here. It is released under the Creative Commons Attribution-Share-Alike License 3.0.



Music Scenes