Landscape near Irenopolis
Irenopolis or Eirenopolis (Greek: ) was an ancient Roman, Byzantine and medieval city in northeastern Cilicia, not far from the Calycadnus river, also known briefly as Neronias (Greek: ) in honour of the Roman emperor Nero. Irenopolis was also an episcopal see that is now included in the Catholic Church's list of titular sees.
It is located on the site of Düziçi (formerly Haruniye) in the province of Osmaniye. Located at the mouth of the Darb al-'Ain pass, which led from al-H?r?n?ya to Germanikeia, 104 km SE of Adana and 29.5 km NE of Osmaniye.E. Honigmann's identification of Irenopolis with Bagdacik, the "little Irenopolis" (in contrast to the "great Irenopolis"), 25 km NE of Osmaniye on the way to Hasanbeyli, is wrong because the area is called Bu?daycik  The site is a little higher than Hierapolis Kastabala and Anazarbus, on the mountain preventing access to the Cilician plain from the east.
It was probably founded by Antiochus IV of Commagene. The coins of the city show that Asclepius and Hygeia were worshiped in the city during pagan era. The cult of the two gods in the city may be connected with the natural spring of the area.
Theodoret of Cyrus confirms that the two names, Eirenopolis and Neronias, apparently refer to the same city. The name Neronias refereeing to honors bestowed on the city by Nero. The city is mentioned by Hierocles Nicephore and Calliste. The city came under Muslim rule following the Battle of Manzikert in 1071.
Christianity first came to the area in the 1st century the strategic location through the mountain passess, and the work of St Paul made it an early candidate for missionaries. The city was the seat of a bishopric in Byzantine times.