Klosé is noted for his design improvements to the clarinet using the principles laid down by Theobald Boehm in his innovative work on the flute keywork. From 1839 to 1843, he enlisted the help of Louis-August Buffet of Buffet-Crampon fame, an instrument-making technician, to construct — what is known today as — the Boehm system clarinet.
Klosé was second clarinet at the Théâtre Italien to Frédéric Berr beginning in 1836, then to Iwan Müller following Berr's death in 1838, finally becoming solo clarinet when Müller left in 1841. Klosé also wrote Air varie pour ophicleide et Piano (op. 21) which is available on a recording by the Trio Aenea, 2015.
In the Paris Conservatory, Klosé had many notable pupils including:
2. Paul, Jean-Marie - Hyacinthe Klosé (1808-1880): His Works for Clarinet -The Clarinet,2006, vol. 33/3, pp66-71
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