Given command of the French army in Italy by Francis I of France during the Italian War of 1542, he was the French commander at the Franco-Ottoman Siege of Nice in 1543, and he led it to victory at the Battle of Ceresole in 1544.
His early death at the age of 26 was caused by an accident - specifically by the falling of a heavy chest - in the castle La Roche-Guyon. He was succeeded as Count of Enghien by his younger brother John.
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