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IUPAC name
3D model (JSmol)
Molar mass 195.26 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

DMA, or dimethoxyamphetamine, is a series of six lesser-known psychedelic drugs similar in structure to the three isomers of Methoxyamphetamine and six isomers of trimethoxyamphetamine. The isomers are 2,3-DMA, 2,4-DMA, 2,5-DMA, 2,6-DMA, 3,4-DMA, and 3,5-DMA. They were first collectively characterized by Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known And Loved).[1] Little is known about their dangers or toxicity.

Positional isomers


2,4-DMA, or 2,4-dimethoxy-amphetamine
  • Dosage: 60 mg or greater
  • Duration: "Probably short."
  • Effects: stimulative, amphetamine-like effects


2,5-DMA, or 2,5-dimethoxy-amphetamine

2,5-DMA is the alpha-methyl homologue of 2C-H and could be called "DOH" under the DO naming scheme.


3,4-DMA, or 3,4-dimethoxy-amphetamine

Note that two other positional isomers of dimethoxyamphetamine, 2,6-DMA and 3,5-DMA, have also been made, but these drugs have not been tested in humans and their effects are unknown. However, it is likely that these compounds would also produce amphetamine-like stimulation or possibly hallucinogenic effects.

3,4-DMA has known use as a precursor in the synthesis of dimoxyline.[4]

Legal Status

United States

2,5-dimethoxyamphetamine is listed as a Scheduled I controlled substance at the federal level in the United States and is therefore illegal to buy, possess, and sell.[5] 2,4-dimethoxyamphetamine, 2,6-dimethoxyamphetamine, 3,4-dimethoxyamphetamine, and 3,5-dimethoxyamphetamine are each position isomers of 2,5-dimethoxyamphetamine, they are therefore all Schedule I controlled substances as well.


DMA is considered a Schedule 9 prohibited substance in Australia under the Poisons Standard (October 2015).[6] A Schedule 9 substance is a substance which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities.[6]

New Zealand

DMA is considered a Class A controlled drug under the Misuse of Drugs Act 1975[7]

See also


  1. ^ a b c Shulgin, Alexander; Ann Shulgin (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628.
  2. ^ "PiHKAL". isomerdesign.com. Retrieved .
  3. ^ Baltzly, Richard; Buck, Johannes S. (1940). "Amines Related to 2,5-Dimethoxyphenethylamine". Journal of the Chemical Society. 62: 161-164.
  4. ^ Drugfuture.com/chemdata/dimoxyline.html
  5. ^ §1308.11 Schedule I.
  6. ^ a b Poisons Standard October 2015 https://www.comlaw.gov.au/Details/F2015L01534
  7. ^ "Misue of Drugs Act 1975". New Zealand Government. Retrieved .

External links

  This article uses material from the Wikipedia page available here. It is released under the Creative Commons Attribution-Share-Alike License 3.0.



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