Cutaneous Conditions With Immunofluorescence Findings
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Cutaneous Conditions With Immunofluorescence Findings

Several cutaneous conditions can be diagnosed with the aid of immunofluorescence studies.

Cutaneous conditions with positive direct or indirect immunofluorescence when using salt-split skin include:

Antibody isotype(s) and location of antibody deposition in immunofluorescence studies using salt-split skin for autoimmune bullous conditions targeting the basement membrane zone of the human integumentary system
Condition Antibody isotype(s) deposited Localization of antibody with use of salt-split skin
Antiepilegrin cicatricial pemphigoid IgG Dermal
Bullous lupus erythematosus Dermal
Bullous pemphigoid IgG Epidermal
Cicatricial pemphigoid IgG Epidermal
Epidermolysis bullosa acquisita IgG Dermal
Linear IgA bullous dermatosis IgA Epidermal
Orf-induced immunobullous disease IgG Dermal
Pemphigoid gestationis IgG Epidermal

For several subtypes of pemphigus a variety of substrates are used for indirect immunofluorescence:

Substrates used in indirect immunofluorescence studies for the different pemphigus variants
Pemphigus variant Substrate
Pemphigus foliaceous Guinea pig esophagus
Pemphigus vulgaris Monkey esophagus
IgA pemphigus Cultured skin
Paraneoplastic pemphigus Rat bladder

See also


  • Bolognia, Jean L.; et al. (2007). Dermatology. St. Louis: Mosby. ISBN 1-4160-2999-0.
  • James, William D.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.

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