The School of Antioch was one of the two major centers of the study of biblical exegesis and theology during Late Antiquity; the other was the Catechetical School of Alexandria. This group was known by this name because the advocates of this tradition were based in the city of Antioch, one of the major cities of the ancient Roman Empire.
While the Christian intellectuals of Alexandria emphasized the allegorical interpretation of Scriptures and tended toward a Christology that emphasized the union of the human and the divine, those in Antioch held to a more literal and occasionally typological exegesis and a Christology that emphasized the distinction between the human and the divine in the person of Jesus Christ. The school in general tended to what might be called, in a rather loose sense, an Adoptionist Christology.Nestorius, before becoming Patriarch of Constantinople, had been a monk at Antioch and had there become imbued with the principles of the Antiochene theological school.
The school of Antioch is best divided into three periods:
The earliest author known of this period is Theophilus of Antioch. Then there is a gap of a century and in the first half of the fifth century there are three known antiochene authors: the best known is Eusebius of Emesa; other representatives are Acacius of Caesarea and Theodore bishop of Heraklea.
This period includes at least three different generations: Diodorus of Tarsus, who directed an ? (school) he may have founded. Among his disciples, the best known are John Chrysostom and Theodorus of Mopsuestia. The main figure of the third generation was Nestorius.
After the Council of Ephesus (431), the School of Antioch lost some of its prestige. However, after the Council of Chalcedon (451), the Antiochian school became the sole theological school within Eastern and Western Christianity, where the Far-Eastern Churches adopted the Alexandrian School of Theology. Apparently only two later authors are known: Basil of Seleucia and Gennadius of Constantinople.