Aprepitant (Emend) is a commercially available NK1 Receptor antagonist
Casopitant is an investigational NK1 receptor antagonist
Rolapitant (Varubi) another recently approved drug from this class
Antihistamines (H1 histamine receptor antagonists) are effective in many conditions, including motion sickness, morning sickness in pregnancy, and to combat opioid nausea. H1 receptors in central areas include area postrema and vomiting center in the vestibular nucleus. Also, many of the antihistamines have anticholinergic properties that block muscarinic receptors at the same sites.
Dexamethasone (Decadron) is given in low dose at the onset of a general anesthetic as an effective antiemetic. It is also used in chemotherapy as a single drug as well as with other antiemetics such as 5-HT3 receptor antagonists and NK1 receptor antagonist, but the specific mechanism of action is not fully understood.
^Pae C-U (2006). "Low-dose mirtazapine may be successful treatment option for severe nausea and vomiting". Progress in Neuro-Psychopharmacology and Biological Psychiatry. 30 (6): 1143-5. doi:10.1016/j.pnpbp.2006.03.015. PMID16632163.
^Kast RE, Foley KF (July 2007). "Cancer chemotherapy and cachexia: mirtazapine and olanzapine are 5-HT3 antagonists with good antinausea effects". European Journal of Cancer Care. 16 (4): 351-4. doi:10.1111/j.1365-2354.2006.00760.x. PMID17587360.
^National Institute of Mental Health. PDSD Ki Database (Internet) [cited 2013 Sep 27]. Chapel Hill (NC): University of North Carolina. 1998-2013. Available from: "Archived copy". Archived from the original on 2013-11-08. Retrieved .CS1 maint: archived copy as title (link)
^Abdel-Aziz H, Windeck T, Ploch M, Verspohl EJ (2006-01-13), "Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum", Eur J Pharmacol, 530 (1-2): 136-43, doi:10.1016/j.ejphar.2005.10.049, PMID16364290