Androstadienone
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Androstadienone
Androstadienone
Androstadienone chemical structure.png
Clinical data
ATC code
  • none
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC19H26O
Molar mass270.408 g/mol g·mol-1
3D model (JSmol)
 ?N?Y (what is this?)  (verify)

Androstadienone, also known as androsta-4,16-dien-3-one, is an endogenous steroid that has been described as having potent pheromone-like activities in humans.[1] The compound is synthesized from androstadienol by 3?-hydroxysteroid dehydrogenase, and can be converted into androstenone (a more potent and odorous pheromone) by 5?-reductase, which can subsequently be converted into 3?-androstenol or 3?-androstenol (also more potent and odorous pheromones) by 3-ketosteroid reductase.[2]

Androstadienone is related to the androgen sex hormones; however, androstadienone does not exhibit any androgenic or anabolic effects. Though it has been reported to significantly affect the mood of heterosexual women and homosexual men, it does not alter behavior overtly,[3][4][5][6] although it may have more subtle effects on attention.[7]

Androstadienone is commonly sold in male fragrances; it is purported to increase sexual attraction. Androstadienone, in picogram quantities, has been shown to have "significant reduction of nervousness, tension and other negative feeling states" in female subjects.[8]

See also

References

  1. ^ Wyart C, Webster WW, Chen JH, Wilson SR, McClary A, Khan RM, Sobel N (February 2007). "Smelling a single component of male sweat alters levels of cortisol in women". J Neurosci. 27 (6): 1261-5. doi:10.1523/JNEUROSCI.4430-06.2007. PMID 17287500.
  2. ^ Joseph Johannes; Agnes Maria Weusten (1989). Biochemical pathways in human testicular steroidogenesis (PDF). Pressa Trajectina.
  3. ^ Lundström JN, Olsson MJ (December 2005). "Subthreshold amounts of social odorant affect mood, but not behavior, in heterosexual women when tested by a male, but not a female, experimenter". Biol Psychol. 70 (3): 197-204. doi:10.1016/j.biopsycho.2005.01.008. PMID 16242537.
  4. ^ "Mens' Sweat Pheromone, Androstadienone, Influences Cooperation In Other Men". Retrieved 2016.
  5. ^ "Human Pheromone Molecules". Archived from the original on March 14, 2016. Retrieved 2016.
  6. ^ "Human Sexual Responses Boosted by Bodily Scents". Retrieved 2016.
  7. ^ Hummer TA, McClintock MK (April 2009). "Putative human pheromone androstadienone attunes the mind specifically to emotional information". Horm Behav. 55 (4): 548-59. doi:10.1016/j.yhbeh.2009.01.002. PMID 19470369.
  8. ^ Grosser, B (2000). "Behavioral and electrophysiological effects of androstadienone, a human pheromone". Psychoneuroendocrinology. 25 (3): 289-99. doi:10.1016/s0306-4530(99)00056-6. PMID 10737699.

External links



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Androstadienone
 



 



 
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