An amphiphile (from the Greek , amphis: both and í?, philia: love, friendship) is a chemical compound possessing both hydrophilic (water-loving, polar) and lipophilic (fat-loving) properties. Such a compound is called amphiphilic or amphipathic. This forms the basis for a number of areas of research in chemistry and biochemistry, notably that of lipid polymorphism. Organic compounds containing hydrophilic groups at both ends of a prolate (in the aggregate) molecule are called bolaamphiphilic. Common amphiphilic substances are soaps, detergents, and lipoproteins.
The hydrophilic group falls into one of the following categories:
When placed in an immiscible biphasic system consisting of aqueous and organic solvents, the amphiphilic compound will partition the two phases. The extent of the hydrophobic and hydrophilic portions determines the extent of partitioning.
Phospholipids, a class of amphiphilic molecules, are the main components of biological membranes. The amphiphilic nature of these molecules defines the way in which they form membranes. They arrange themselves into bilayers, by positioning their polar groups towards the surrounding aqueous media (respectively the extracellular fluid and the intracellular solution, the cytosol), and their lipophilic chains towards the inside of the bilayer, defining a non-polar region between the two polar ones.
Although phospholipids are the principal constituents of biological membranes, there are other constituents, such as cholesterol and glycolipids, which are also included in these structures and give them different physical and biological properties.
Many other amphiphilic compounds, such as pepducins, strongly interact with biological membranes by insertion of the hydrophobic part into the lipid membrane, while exposing the hydrophilic part to the aqueous medium, altering their physical behavior and sometimes disrupting them.
A? proteins form antiparallel ? sheets which are strongly amphiphilic, and which aggregate to form toxic oxidative A? fibrils. A? fibrils themselves are composed of amphiphilic 13-mer modular ? sandwiches separated by reverse turns. Hydropathic waves optimize the description of the small (40,42 aa) plaque-forming (aggregative) A? fragments.
Antimicrobial peptides are another class of amphiphilic molecules, a big data analysis showed that amphipathicity best distinguished between AMPs with and without anti-gram-negative bacteria activities. The higher amphipathicity, the better chances for AMPs possessing antibacterial and antifungal dual activities.
There are several examples of molecules that present amphiphilic properties:
Hydrocarbon-based surfactants are an example group of amphiphilic compounds. Their polar region can be either ionic, or non-ionic. Some typical members of this group are: sodium dodecyl sulfate (anionic), benzalkonium chloride (cationic), cocamidopropyl betaine (zwitterionic), and 1-octanol (long-chain alcohol, non-ionic).
Soap is a common household amphiphilic compound. Soap mixed with water (polar, hydrophilic) is useful for cleaning oils and fats (non-polar, lipiphillic) from kitchenware, dishes, skin, clothing, etc.