Amination
Get Amination essential facts below. View Videos or join the Amination discussion. Add Amination to your PopFlock.com topic list for future reference or share this resource on social media.
Amination

Amination is the process by which an amine group is introduced into an organic molecule. This type of reaction is important because organonitrogen compounds are pervasive.

Reactions

Aminase enzymes

Enzymes that catalyse this reaction are termed aminases. Amination can occur in a number of ways including reaction with ammonia or another amine such as an alkylation, reductive amination and the Mannich reaction. For example, -CO2H --> -CONH2.

Acid-catatlyzed hydroamination

Many alkyl amines are produced industrially by the amination of alcohols using ammonia in the presence of solid acid catalysts. Illustrative is the production of tert-butylamine:

NH3 + CH2=C(CH3)2 -> H2NC(CH3)3
Ritter reaction

The Ritter reaction of isobutene with hydrogen cyanide is not useful in this case because it produces too much waste.[1]

In electrophilic amination, the amine as the nucleophile react with another the organic compound as the electrophile. This sense of reactivity may be reversed for some electron-deficient amines, including oxaziridines, hydroxylamines, oximes, and other N-O substrates. When the amine is used as an electrophile, the reaction is called electrophilic amination. Electron-rich organic substrates that may be used as nucleophiles for this process include carbanions and enolates.

Misccellaneous methods

Alpha hydroxy acids can be converted into amino acids directly using aqueous ammonia solution, hydrogen gas and a heterogeneous metallic ruthenium catalyst.[2]

Metal-catalyzed hydroamination

In hydroamination, amines add to alkenes.[3]

See also

References

  1. ^ Eller, Karsten; Henkes, Erhard; Rossbacher, Roland; Höke, Hartmut (2000). "Amines, Aliphatic". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a02_001.
  2. ^ Deng, Weiping, et al. "Catalytic amino acid production from biomass-derived intermediates." Proceedings of the National Academy of Sciences 115.20 (2018): 5093-5098. doi:10.1073/pnas.1800272115
  3. ^ Liangbin Huang, Matthias Arndt, Käthe Gooßen, Heinrich Heydt, and Lukas J. Gooßen "Late Transition Metal-Catalyzed Hydroamination and Hydroamidation" Chem. Rev., 2015, 115 (7), pp 2596-2697. doi:10.1021/cr300389u

  This article uses material from the Wikipedia page available here. It is released under the Creative Commons Attribution-Share-Alike License 3.0.

Amination
 



 



 
Music Scenes