The Husaynis migrated to Jerusalem in the 12th century after Saladin drove out the Crusaders from the city and much of the Levant.
The Husaynis were a major force in rebelling against Muhammad Ali who governed Egypt and Palestine in defiance of the Ottoman Empire. This solidified a cooperative relationship with the returning Ottoman authority. The clan took part in fighting the Qaisi tribe in an alliance with a rural lord of the Jerusalem area Mustafa Abu Ghosh, who clashed with the tribe frequently. The feuds gradually occurred in the city between the clan and the Khalidis that led the Qaisis, however these conflicts dealt with city positions and not Qaisi-Yamani rivalry. The Husaynis later led opposition and propaganda movements against the Young Turks who controlled the Ottoman Empire.
By the time of the British Mandate the clan had hundreds of members and its several branches encompassed thousands. They were mostly concentrated in the Old City, however a large number of clan members also lived in the neighborhoods of Sheikh Jarrah, the German Colony, Katamon, Baka and Musrara. Several members of the clan were appointed to important political positions such as Mayor and Grand Mufti of Jerusalem. Musa al-Husayni was mayor of Jerusalem, 1918-1920. Mohammed Tahir al-Husayni was Grand Mufti of Jerusalem, 1860s-1908, followed by his son Kamil al-Husayni, 1908-1921, and then another son Mohammad Amin al-Husayni, 1921-1937. The main political rivals for the clan was the Nashashibi clan of Jerusalem, especially during the Mandate period. Before the formal commencement of the British Mandate, Musa and Amin al-Husayni incited the 1920 Palestine riots, resulting in many deaths. As a result, Musa was replaced as mayor by the head of the rival Nashashibi clan.Amin al-Husayni and Aref al-Aref were arrested, but when they were let out on bail they both escaped to Syria. A military court sentenced Amin in absentia to 10 years imprisonment, and he failed to qualify for a general amnesty in early 1921 because of his absence.
Unlike the Nashashibi clan, many Husayni clan members continued to lead opposition and propaganda movements against the British Mandate government and early Zionist immigrants. The clan founded and led many Palestinian Arab Islamist groups such as the Palestine Arab Party and the Arab Higher Committee. The clan was directly involved in disturbances including the 1920 Palestine riots and the 1936-1939 Arab revolt in Palestine. As a result of continuing disturbances and violence, the Arab Higher Committee was outlawed in October 1937 and Arab national leaders were rounded up by the British. One member of the clan, Amin al-Husayni, escaped arrest by fleeing to Syria. During World War II he went to Iraq then Iran and eventually to Italy and eventually arrived in Berlin. In Berlin, Amin al-Husayni was photographed with many important Nazi leaders including Adolf Hitler and Amin al-Husayni went to the Balkans on behalf of the Nazis to give speeches to recruits of the 13th Waffen SS division. Amin al-Husayni also broadcast pro-Axis statements into the Middle East on Nazi radio stations.
After the 1948 War, most of the clan relocated to Jordan and the Gulf States. Many family heads that remained in the Old City and the northern neighborhoods of East Jerusalem fled due to hostilities with the Israeli government. Amin al-Husayni was politically active from Cairo. King Abdullah's assassin was a member of an underground Palestinian organization led by Daoud al-Husayni.
Kamil al-Husayni (23 February 1867 - 31 March 1921) - second Grand Mufti of Jerusalem (1908-1921, followed by his brother Mohammad Amin al-Husayni). (Son of Mustafa Taher al-Husayni; brother of Mohammad Amin al-Husayni).