|Champions League||Apollon (1st qualifying round)|
|UEFA Cup||Omonia (1st qualifying round) |
APOEL (1st qualifying round; via Cypriot Cup))
|UEFA Intertoto||Ethnikos (1st round)|
|Goals scored||603 (3.31 per match)|
|Top goalscorer||?ukasz Sosin|
Fourteen teams participated in the 2005-06 Cypriot First Division. All teams played against each other twice, once at their home and once away. The team with the most points at the end of the season crowned champions. The last three teams were relegated to the 2006-07 Cypriot Second Division.
The teams had to declare their interest to participate in the 2006 UEFA Intertoto Cup before the end of the championship. At the end of the championship, the higher placed team among the interested ones participated in the Intertoto Cup (if they had not secured their participation in any other UEFA competition).
Teams received three points for a win, one point for a draw and zero points for a loss.
AEP Paphos, Alki Larnaca and Aris Limassol were relegated from previous season and played in the 2005-06 Cypriot Second Division. They were replaced by the first three teams of the 2004-05 Cypriot Second Division, APOP Kinyras, APEP and THOI Lakatamia.
|Anorthosis||Antonis Papadopoulos Stadium|
|Ethnikos Achna||Dasaki Stadium|
|Enosis Neon Paralimni||Paralimni Stadium|
|Nea Salamina||Ammochostos Stadium|
|Pos||Team||Pld||W||D||L||GF||GA||GD||Pts||Qualification or relegation|
|1||Apollon Limassol (C)||26||19||7||0||68||24||+44||64||UEFA Champions League 1st qualifying round|
|2||Omonia||26||20||3||3||59||20||+39||63||2006-07 UEFA Cup 1st qualifying round|
|3||APOEL||26||19||5||2||63||22||+41||62||2006-07 UEFA Cup 1st qualifying round and Cypriot Cup Winner|
|5||Enosis Neon Paralimni||26||12||7||7||40||28||+12||43|
|9||Ethnikos Achna||26||8||4||14||42||43||−1||28||2006 UEFA Intertoto Cup 1st round|
|12||APOP Kinyras (R)||26||5||3||18||35||65||−30||18||Relegated to 2006-07 Cypriot Second Division|
|14||THOI Lakatamia (R)||26||1||4||21||15||75||−60||7|