|2000 Arizona Cardinals season|
|Head coach||Vince Tobin|
|Home field||Sun Devil Stadium|
|Division place||5th NFC East|
|Playoff finish||did not qualify|
|Pro Bowlers||P Scott Player|
The 2000 Arizona Cardinals season was the franchise's 102nd season, 81st season in the National Football League and the 13th in Arizona. The Cardinals ranked 24th in the NFL in total offense and 30th in total defense. The Cardinals ranked last in the NFC in Takeaways/Giveaways with a rating of -24.
Two of the Cardinals' three victories came by one point each, and they were 0-8 on the road. Following the most lopsided of those eight road losses, 48-7 at Dallas in week eight, coach Vince Tobin was fired, ending his tenure in the desert after 4½ seasons with a 29-44 record. Defensive coordinator Dave McGinnis was named interim coach, and he held the job through the end of the 2003 season. The 3-13 mark would be matched in 2018.
The Cardinals suffered through their poorest season since the 1970 AFL-NFL merger, eclipsing the 4-12 marks of 1991, 1992, 1995 and 1997. The Cardinals also went 4-9-1 in 1971, 1972 and 1973, and 4-11-1 in 1986, and would suffer through another 4-12 campaign in 2003.
|2000 Arizona Cardinals draft|
|1||7||Thomas Jones *||RB||Virginia|
|5||164||Jay Tant||TE||Northwestern||compensatory selection|
|Pro Football Hall of Fame Made at least one Pro Bowl during careerMade roster|
On December 18, Dave McGinnis was named as the 38th head coach in franchise history. He had been interim coach since October 23, when Vince Tobin was fired.
|1||September 3, 2000||at New York Giants||L 21-16||FOX||0-1|
|2||September 10, 2000||Dallas Cowboys||W 32-31||ESPN||1-1|
|4||September 24, 2000||Green Bay Packers||L 29-3||FOX||1-2|
|5||October 1, 2000||at San Francisco 49ers||L 27-20||FOX||1-3|
|6||October 8, 2000||Cleveland Browns||W 29-21||CBS||2-3|
|7||October 15, 2000||Philadelphia Eagles||L 33-14||FOX||2-4|
|8||October 22, 2000||at Dallas Cowboys||L 48-7||FOX||2-5|
|9||October 29, 2000||New Orleans Saints||L 21-10||FOX||2-6|
|10||November 5, 2000||Washington Redskins||W 16-15||FOX||3-6|
|11||November 12, 2000||at Minnesota Vikings||L 31-14||FOX||3-7|
|12||November 19, 2000||at Philadelphia Eagles||L 34-9||FOX||3-8|
|13||November 26, 2000||New York Giants||L 31-7||ESPN||3-9|
|14||December 3, 2000||at Cincinnati Bengals||L 24-13||FOX||3-10|
|15||December 10, 2000||at Jacksonville Jaguars||L 44-10||FOX||3-11|
|16||December 17, 2000||Baltimore Ravens||L 13-7||CBS||3-12|
|17||December 24, 2000||at Washington Redskins||L 20-3||FOX||3-13|
|(1)New York Giants||12||4||0||.750||328||246||W5|